Alzheimer’s disease (AD) and dementia are a global public health priority, and prevention has been highlighted as a pivotal component in managing the dementia epidemic.
Modifiable risk factors of dementia and AD include lifestyle-related factors, vascular and metabolic disorders, and psychosocial factors.
Given the complex, multifactorial, and heterogeneous nature of late-onset AD and dementia, interventions targeting several risk factors and mechanisms simultaneously may be required for optimal preventive effects.
The Journal of Prevention of Alzheimer's Disease
Nearly two-thirds of these suggestions target vascular risk factors and lifestyle, strengthening the importance of keeping a good vascular condition and maintaining a healthy lifestyle for preventing AD.
Journal of Neurology, Neurosurgery & Psychiatry
Source Reference: Yu J-t, et al "Evidence- based prevention of Alzheimer's disease: systematic review and meta- analysis of 243 observational prospective studies and 153 randomised controlled trials" J Neurol Neurosurg Psychiatry 2020; DOI: 10.1136/jnnp-2019-321913.